Anti-PON1 antibody (9-109) (STJ25056)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PON1 (9-109) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PON1 |
| Gene ID | 5444 |
| Uniprot ID | PON1_HUMAN |
| Immunogen Region | 9-109 |
| Immunogen Sequence | LLGMGLALFRNHQSSYQTRL NALREVQPVELPNCNLVKGI ETGSEDLEILPNGLAFISSG LKYPGIKSFNPNSPGKILLM DLNEEDPTVLELGITGSKFD V |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 9-109 of human PON1 (NP_000437.3). |
Additional Info
| Tissue Specificity | Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas. |
| Post Translational Modifications | Glycosylated. The signal sequence is not cleaved. Present in two forms, form B contains a disulfide bond, form A does not. |
| Function | Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. |
| Protein Name | Serum Paraoxonase/Arylesterase 1Pon 1 Aromatic Esterase 1A-Esterase 1K-45Serum Aryldialkylphosphatase 1 |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-9754706 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Serum Paraoxonase/Arylesterase 1 antibodyAnti-Pon 1 antibodyAnti-Aromatic Esterase 1 antibodyAnti-A-Esterase 1 antibodyAnti-K-45 antibodyAnti-Serum Aryldialkylphosphatase 1 antibodyAnti-PON1 antibodyAnti-PON antibody |
Information sourced from Uniprot.org