| Tissue Specificity | Detected at low levels in testis, spleen, prostate and ovary. Detected at very low levels in kidney, colon, brain, heart, liver, lung, placenta, pancreas and peripheral blood leukocytes. |
| Function | DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. |
| Protein Name | Dna Polymerase KappaDinb ProteinDinp |
| Database Links | Reactome: R-HSA-5655862Reactome: R-HSA-5656169Reactome: R-HSA-5685942Reactome: R-HSA-5696397Reactome: R-HSA-5696400Reactome: R-HSA-6782135Reactome: R-HSA-6782210 |
| Cellular Localisation | NucleusDetected Throughout The Nucleus And At Replication FociRecruited To Dna Damage Sites In Response To Ultraviolet Irradiation: N6-Methyladenosine (M6a)-Containing Mrnas Accumulate In The Vicinity Of Dna Damage Sites And Their Presence Is Required To Recruit Polk |
| Alternative Antibody Names | Anti-Dna Polymerase Kappa antibodyAnti-Dinb Protein antibodyAnti-Dinp antibodyAnti-POLK antibodyAnti-DINB1 antibody |
Information sourced from Uniprot.org
