| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | POLK |
| Gene ID: | 51426 |
| Uniprot ID: | POLK_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human POLK (NP_057302.1). |
| Immunogen Sequence: | MDSTKEKCDSYKDDLLLRMG LNDNKAGMEGLDKEKINKII MEATKGSRFYGNELKKEKQV NQRIENMMQQKAQITSQQLR KAQLQVDRFAMELEQSRNLS |
| Tissue Specificity | Detected at low levels in testis, spleen, prostate and ovary. Detected at very low levels in kidney, colon, brain, heart, liver, lung, placenta, pancreas and peripheral blood leukocytes. |
| Function | DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. |
| Protein Name | Dna Polymerase KappaDinb ProteinDinp |
| Database Links | Reactome: R-HSA-5655862Reactome: R-HSA-5656169Reactome: R-HSA-5685942Reactome: R-HSA-5696397Reactome: R-HSA-5696400Reactome: R-HSA-6782135Reactome: R-HSA-6782210 |
| Cellular Localisation | NucleusDetected Throughout The Nucleus And At Replication FociRecruited To Dna Damage Sites In Response To Ultraviolet Irradiation: N6-Methyladenosine (M6a)-Containing Mrnas Accumulate In The Vicinity Of Dna Damage Sites And Their Presence Is Required To Recruit Polk |
| Alternative Antibody Names | Anti-Dna Polymerase Kappa antibodyAnti-Dinb Protein antibodyAnti-Dinp antibodyAnti-POLK antibodyAnti-DINB1 antibody |
Information sourced from Uniprot.org
