Anti-POLE3 antibody (STJA0007579)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human POLE3
General Information
| Short Description | Rabbit polyclonal anti-DNA polymerase epsilon subunit 3 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | POLE3 |
| Gene ID | 54107 |
| Uniprot ID | DPOE3_HUMAN |
| Immunogen | Synthesized peptide derived from human POLE3 |
| Specificity | This antibody detects endogenous levels of POLE3 at Human, Mouse, Rat |
Additional Info
| Function | Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication. Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex. |
| Protein Name | Dna Polymerase Epsilon Subunit 3Arsenic-Transactivated ProteinAstpChromatin Accessibility Complex 17 Kda ProteinChrac-17Huchrac17Dna Polymerase Ii Subunit 3Dna Polymerase Epsilon Subunit P17 |
| Database Links | Reactome: R-HSA-110314Reactome: R-HSA-5651801Reactome: R-HSA-5656169Reactome: R-HSA-5685942Reactome: R-HSA-5696397Reactome: R-HSA-5696400Reactome: R-HSA-6782135Reactome: R-HSA-6782210Reactome: R-HSA-68952Reactome: R-HSA-68962 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dna Polymerase Epsilon Subunit 3 antibodyAnti-Arsenic-Transactivated Protein antibodyAnti-Astp antibodyAnti-Chromatin Accessibility Complex 17 Kda Protein antibodyAnti-Chrac-17 antibodyAnti-Huchrac17 antibodyAnti-Dna Polymerase Ii Subunit 3 antibodyAnti-Dna Polymerase Epsilon Subunit P17 antibodyAnti-POLE3 antibodyAnti-CHRAC17 antibody |
Information sourced from Uniprot.org