| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POGLUT1 |
| Gene ID: |
56983 |
| Uniprot ID: |
PGLT1_HUMAN |
| Immunogen Region: |
160-280 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 160-280 of human POGLUT1 (NP_689518.1). |
| Immunogen Sequence: |
MYPAWTFWEGGPAVWPIYPT GLGRWDLFREDLVRSAAQWP WKKKNSTAYFRGSRTSPERD PLILLSRKNPKLVDAEYTKN QAWKSMKDTLGKPAAKDVHL VDHCKYKYLFNFRGVAASFR F |
| Tissue Specificity | Expressed in most adult tissues at different intensities. Abundantly expressed in liver. Expressed also in brain, heart, skeletal muscle, spleen, kidney, placenta, lung and peripheral blood leukocyte. Not detectable in colon, thymus and small intestine. Expressed in the epidermis, especially in the upper parts, stratum spinosum and stratum granulosum (at protein level). |
| Function | Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C. Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2. Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development. Notch glucosylation does not affect Notch ligand binding. Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane. |
| Protein Name | Protein O-Glucosyltransferase 1Cap10-Like 46 Kda ProteinHclp46Ktel Motif-Containing Protein 1Myelodysplastic Syndromes Relative ProteinO-Glucosyltransferase Rumi HomologHrumiProtein O-Xylosyltransferase Poglut1 |
| Database Links | Reactome: R-HSA-1912399 |
| Cellular Localisation | Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Protein O-Glucosyltransferase 1 antibodyAnti-Cap10-Like 46 Kda Protein antibodyAnti-Hclp46 antibodyAnti-Ktel Motif-Containing Protein 1 antibodyAnti-Myelodysplastic Syndromes Relative Protein antibodyAnti-O-Glucosyltransferase Rumi Homolog antibodyAnti-Hrumi antibodyAnti-Protein O-Xylosyltransferase Poglut1 antibodyAnti-POGLUT1 antibodyAnti-C3orf9 antibodyAnti-CLP46 antibodyAnti-KTELC1 antibodyAnti-MDSRP antibodyAnti-MDS010 antibodyAnti-UNQ490 antibodyAnti-PRO1006 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
