| Function | Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors. Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former. Has also a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono-unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine. However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling. On the other hand, can produce arachidonic acid from the sn-1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates. Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers. Can also hydrolyze lysophosphatidylcholine. In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling. It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition. |
| Protein Name | Calcium-Independent Phospholipase A2-GammaIntracellular Membrane-Associated Calcium-Independent Phospholipase A2 GammaIpla2-GammaPnpla-GammaPatatin-Like Phospholipase Domain-Containing Protein 8Ipla2-2 |
| Database Links | Reactome: R-HSA-1482788Reactome: R-HSA-1482839 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinMitochondrion MembranePeroxisome Membrane |
| Alternative Antibody Names | Anti-Calcium-Independent Phospholipase A2-Gamma antibodyAnti-Intracellular Membrane-Associated Calcium-Independent Phospholipase A2 Gamma antibodyAnti-Ipla2-Gamma antibodyAnti-Pnpla-Gamma antibodyAnti-Patatin-Like Phospholipase Domain-Containing Protein 8 antibodyAnti-Ipla2-2 antibodyAnti-PNPLA8 antibodyAnti-IPLA22 antibodyAnti-IPLA2G antibodyAnti-BM-043 antibody |
Information sourced from Uniprot.org
