Anti-PNOC antibody (Internal) (STJ73552)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PNOC (Internal) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Not yet tested-our routinely used western blotting protocol does not allow detection of mature proteins much smaller than the calculated size of 20.3kDa according to the precursor NP_0 |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PNOC |
| Gene ID | 5368 |
| Uniprot ID | PNOC_HUMAN |
| Accession Number | NP_006219.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | PRVRSLFQEQE |
Additional Info
| Post Translational Modifications | Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin. The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. |
| Function | Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia. Orphanin FQ2: Has potent analgesic activity. |
| Protein Name | Prepronociceptin Cleaved Into - Nocistatin - NociceptinOrphanin FqPpnoc - Orphanin Fq2 |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Prepronociceptin Cleaved Into - Nocistatin - Nociceptin antibodyAnti-Orphanin Fq antibodyAnti-Ppnoc - Orphanin Fq2 antibodyAnti-PNOC antibodyAnti-OFQ antibody |
Information sourced from Uniprot.org