| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Plexin D1 (Sema Domain) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: |
Antigen Affinity Purified |
| Dilution Range: |
WB 1:500IHCICCIP |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLXND1 |
| Gene ID: |
23129 |
| Uniprot ID: |
PLXD1_HUMAN |
| Immunogen Region: |
Sema Domain |
| Specificity: |
The antibody detects 250, 215, and 195 kDa bands corresponding to the apparent molecular mass of Plexin D1 variants in human umbilical vein endothelial cells. |
| Immunogen: |
Plexin D1 synthetic peptide (coupled to carrier protein) corresponds to amino acids in the semaphorin domain from human Plexin D1. This sequence is well conserved in rat and mouse Plexin D1, and has low homology to other Plexin family members. |
| Function | Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature. Mediates anti-angiogenic signaling in response to SEMA3E. |
| Protein Name | Plexin-D1 |
| Database Links | Reactome: R-HSA-416700Reactome: R-HSA-9013508Reactome: R-HSA-9696270 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinCell ProjectionLamellipodium Membrane |
| Alternative Antibody Names | Anti-Plexin-D1 antibodyAnti-PLXND1 antibodyAnti-KIAA0620 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
