| Tissue Specificity | Ubiquitous. Detected in heart, placenta and pancreas and at lower levels in lung, liver and skeletal muscle. |
| Function | Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procollagen. Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine. Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues. Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues. Essential for normal biosynthesis and secretion of type IV collagens (Probable). Essential for normal formation of basement membranes. |
| Protein Name | Multifunctional Procollagen Lysine Hydroxylase And Glycosyltransferase Lh3 Includes - Procollagen-Lysine -2-Oxoglutarate 5-Dioxygenase 3Lysyl Hydroxylase 3Lh3 - Procollagen GlycosyltransferaseGalactosylhydroxylysine-GlucosyltransferaseProcollagen GalactosyltransferaseProcollagen Glucosyltransferase |
| Database Links | Reactome: R-HSA-1650814 |
| Cellular Localisation | Rough Endoplasmic ReticulumEndoplasmic Reticulum LumenEndoplasmic Reticulum MembranePeripheral Membrane ProteinLumenal SideSecretedExtracellular SpaceThe Majority Of The Secreted Protein Is Associated With The Extracellular Matrix |
| Alternative Antibody Names | Anti-Multifunctional Procollagen Lysine Hydroxylase And Glycosyltransferase Lh3 Includes - Procollagen-Lysine -2-Oxoglutarate 5-Dioxygenase 3 antibodyAnti-Lysyl Hydroxylase 3 antibodyAnti-Lh3 - Procollagen Glycosyltransferase antibodyAnti-Galactosylhydroxylysine-Glucosyltransferase antibodyAnti-Procollagen Galactosyltransferase antibodyAnti-Procollagen Glucosyltransferase antibodyAnti-PLOD3 antibody |
Information sourced from Uniprot.org
