| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PLOD1 |
| Gene ID: | 5351 |
| Uniprot ID: | PLOD1_HUMAN |
| Immunogen Region: | 19-295 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-295 of human PLOD1 (NP_000293.2). |
| Immunogen Sequence: | KGDAKPEDNLLVLTVATKET EGFRRFKRSAQFFNYKIQAL GLGEDWNVEKGTSAGGGQKV RLLKKALEKHADKEDLVILF ADSYDVLFASGPRELLKKFR QARSQVVFSAEELIYPDRRL ETKYPVVSDGKRFLGSGGFI GYAPNLSKLVAEWEGQDSDS DQLFYTKIFLDPEKREQINI TLDHRCRIFQNLDGALDEVV LKFEMGHVRARNLAYDTLPV LIHGNGPTKLQLNYLGNYI |
| Function | Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (Probable). |
| Protein Name | Procollagen-Lysine -2-Oxoglutarate 5-Dioxygenase 1Lysyl Hydroxylase 1Lh1 |
| Database Links | Reactome: R-HSA-1650814 |
| Cellular Localisation | Rough Endoplasmic Reticulum MembranePeripheral Membrane ProteinLumenal Side |
| Alternative Antibody Names | Anti-Procollagen-Lysine -2-Oxoglutarate 5-Dioxygenase 1 antibodyAnti-Lysyl Hydroxylase 1 antibodyAnti-Lh1 antibodyAnti-PLOD1 antibodyAnti-LLH antibodyAnti-PLOD antibody |
Information sourced from Uniprot.org