• Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200

Anti-PLK2 antibody (377-451 aa) (STJ98963)

SKU:
STJ98963

Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Serine/threonine-protein kinase PLK2 (377-451 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-200
ELISA 1:10000-20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PLK2
Gene ID: 10769
Uniprot ID: PLK2_HUMAN
Immunogen Region: 377-451 aa
Specificity: The antibody detects endogenous PLK2
Immunogen: Synthetic peptide from the human protein at the amino acid range 377-451
Post Translational Modifications Catalytic activity is enhanced by phosphorylation of Thr-239.
Function Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.
Protein Name Serine/Threonine-Protein Kinase Plk2
Polo-Like Kinase 2
Plk-2
Hplk2
Serine/Threonine-Protein Kinase Snk
Hsnk
Serum-Inducible Kinase
Database Links Reactome: R-HSA-6804115
Reactome: R-HSA-9662834
Reactome: R-HSA-9768919
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Centriole
Cell Projection
Dendrite
Localizes To Centrosomes During Early G1 Phase Where It Only Associates To The Mother Centriole And Then Distributes Equally To Both Mother And Daughter Centrioles At The Onset Of S Phase
Alternative Antibody Names Anti-Serine/Threonine-Protein Kinase Plk2 antibody
Anti-Polo-Like Kinase 2 antibody
Anti-Plk-2 antibody
Anti-Hplk2 antibody
Anti-Serine/Threonine-Protein Kinase Snk antibody
Anti-Hsnk antibody
Anti-Serum-Inducible Kinase antibody
Anti-PLK2 antibody
Anti-SNK antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance