Anti-PLIN5 antibody (80-130 aa) (STJ194666)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human PLIN5 at the amino acid range 80-130
General Information
| Short Description | Rabbit polyclonal anti-Perilipin-5 (80-130 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLIN5 |
| Gene ID | 440503 |
| Uniprot ID | PLIN5_HUMAN |
| Immunogen | Synthesized peptide derived from the human PLIN5 at the amino acid range 80-130 |
| Immunogen Region | 80-130 aa |
| Specificity | This antibody detects endogenous levels of PLIN5 at Human/Mouse |
Additional Info
| Post Translational Modifications | Phosphorylated by PKA. Phosphorylated on serine in skeletal muscle at rest or upon lipolytic stimulation. |
| Function | Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE. |
| Protein Name | Perilipin-5Lipid Storage Droplet Protein 5 |
| Database Links | |
| Cellular Localisation | Lipid DropletCytoplasmMitochondrionLipid Droplet Surface-AssociatedExchanges Between Lipid Droplets And The Cytoplasm |
| Alternative Antibody Names | Anti-Perilipin-5 antibodyAnti-Lipid Storage Droplet Protein 5 antibodyAnti-PLIN5 antibodyAnti-LSDP5 antibodyAnti-OXPAT antibodyAnti-PAT-1 antibody |
Information sourced from Uniprot.org