| Host: |
Mouse |
| Applications: |
WB/ICC/IP |
| Reactivity: |
Chicken/Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-PLC Gamma 1 (N-Term) is suitable for use in Western Blot, Immunocytochemistry and Immunoprecipitation research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
M156 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Purification: |
Antigen Affinity Purified |
| Dilution Range: |
WB 1:1000ICC 1:100IP 1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLCG1 |
| Gene ID: |
5335 |
| Uniprot ID: |
PLCG1_HUMAN |
| Immunogen Region: |
N-Term |
| Specificity: |
The antibody detects a 150 kDa* protein in human A431, Hct116, and Jurkat cells, as well as in mouse brain. |
| Immunogen: |
Clone (M156) was generated from a synthetic peptide corresponding to amino acids in the N-terminal region of human PLC Gamma 1. This sequence is highly conserved in rat and mouse PLC Gamma 1, and has low homology to PLC Gamma 2. |
| Function | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. Guanine nucleotide exchange factor that binds the GTPase DNM1 and catalyzes the dissociation of GDP, allowing a GTP molecule to bind in its place, therefore enhancing DNM1-dependent endocytosis. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-1Plc-148Phosphoinositide Phospholipase C-Gamma-1Phospholipase C-IiPlc-IiPhospholipase C-Gamma-1Plc-Gamma-1 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-1236382Reactome: R-HSA-1251932Reactome: R-HSA-1489509Reactome: R-HSA-167021Reactome: R-HSA-1855204Reactome: R-HSA-186763Reactome: R-HSA-201556Reactome: R-HSA-202433Reactome: R-HSA-2029485Reactome: R-HSA-210990Reactome: R-HSA-212718Reactome: R-HSA-2424491Reactome: R-HSA-2871796Reactome: R-HSA-2871809Reactome: R-HSA-418890Reactome: R-HSA-5218921Reactome: R-HSA-5637810Reactome: R-HSA-5654219Reactome: R-HSA-5654221Reactome: R-HSA-5654227Reactome: R-HSA-5654228Reactome: R-HSA-5655253Reactome: R-HSA-5655291Reactome: R-HSA-5655302Reactome: R-HSA-5655332Reactome: R-HSA-8853659Reactome: R-HSA-9026527Reactome: R-HSA-9027277Reactome: R-HSA-9034793Reactome: R-HSA-9664323Reactome: R-HSA-9664565Reactome: R-HSA-9665348Reactome: R-HSA-9665686Reactome: R-HSA-9725370 |
| Cellular Localisation | Cell ProjectionLamellipodiumRuffleRapidly Redistributed To Ruffles And Lamellipodia Structures In Response To Epidermal Growth Factor (Egf) Treatment |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Gamma-1 antibodyAnti-Plc-148 antibodyAnti-Phosphoinositide Phospholipase C-Gamma-1 antibodyAnti-Phospholipase C-Ii antibodyAnti-Plc-Ii antibodyAnti-Phospholipase C-Gamma-1 antibodyAnti-Plc-Gamma-1 antibodyAnti-PLCG1 antibodyAnti-PLC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
