| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PLCB2 |
| Gene ID: | 5330 |
| Uniprot ID: | PLCB2_HUMAN |
| Immunogen Region: | 1-199 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human PLCB2 (NP_004564.2). |
| Immunogen Sequence: | MSLLNPVLLPPKVKAYLSQG ERFIKWDDETTVASPVILRV DPKGYYLYWTYQSKEMEFLD ITSIRDTRFGKFAKMPKSQK LRDVFNMDFPDNSFLLKTLT VVSGPDMVDLTFHNFVSYKE NVGKAWAEDVLALVKHPLTA NASRSTFLDKILVKLKMQLN SEGKIPVKNFFQMFPADRKR VEAALSACHLPKGKNDAIN |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-2Phosphoinositide Phospholipase C-Beta-2Phospholipase C-Beta-2Plc-Beta-2 |
| Database Links | Reactome: R-HSA-112043Reactome: R-HSA-1855204Reactome: R-HSA-399997Reactome: R-HSA-4086398Reactome: R-HSA-416476Reactome: R-HSA-418217Reactome: R-HSA-434316Reactome: R-HSA-500657Reactome: R-HSA-9717207 |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-2 antibodyAnti-Phosphoinositide Phospholipase C-Beta-2 antibodyAnti-Phospholipase C-Beta-2 antibodyAnti-Plc-Beta-2 antibodyAnti-PLCB2 antibody |
Information sourced from Uniprot.org