| Short Description : | Rabbit monoclonal PLC beta 3 (PLCB3) (1100-1200) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S3MR |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PLCB3 |
| Gene ID: | 5331 |
| Uniprot ID: | PLCB3_HUMAN |
| Immunogen Region: | 1100-1200 |
| Immunogen Sequence: | RKRHNSISEAKMRDKHKKEA ELTEINRRHITESVNSIRRL EEAQKQRHDRLVAGQQQVLQ QLAEEEPKLLAQLAQECQEQ RARLPQEIRRSLLGEMPEGL G |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1100-1200 of human PLC beta 3 (PLC beta 3 (PLCB3) ) (Q01970). |
| Function | Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses. |
| Protein Name | 1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-3Phosphoinositide Phospholipase C-Beta-3Phospholipase C-Beta-3Plc-Beta-3 |
| Database Links | Reactome: R-HSA-112043Reactome: R-HSA-1855204Reactome: R-HSA-399997Reactome: R-HSA-4086398Reactome: R-HSA-416476Reactome: R-HSA-418217Reactome: R-HSA-434316Reactome: R-HSA-500657 |
| Cellular Localisation | CytoplasmMembraneNucleusAnd Particulate Fractions |
| Alternative Antibody Names | Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-3 antibodyAnti-Phosphoinositide Phospholipase C-Beta-3 antibodyAnti-Phospholipase C-Beta-3 antibodyAnti-Plc-Beta-3 antibodyAnti-PLCB3 antibody |
Information sourced from Uniprot.org
