Anti-PLB1 antibody (72-122) (STJA0006544)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PLB1 AA range: 72-122
General Information
| Short Description | Rabbit polyclonal anti-Phospholipase B1, membrane-associated (72-122) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PLB1 |
| Gene ID | 151056 |
| Uniprot ID | PLB1_HUMAN |
| Immunogen | Synthesized peptide derived from human PLB1 AA range: 72-122 |
| Immunogen Region | 72-122 |
| Specificity | This antibody detects endogenous levels of human PLB1 |
Additional Info
| Post Translational Modifications | Undergoes proteolytic cleavage in the ileum. |
| Function | Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border. |
| Protein Name | Phospholipase B1 - Membrane-AssociatedPhospholipase BHplbLysophospholipasePhospholipase A2Phospholipase B/LipasePlb/LipTriacylglycerol Lipase |
| Database Links | Reactome: R-HSA-1482788Reactome: R-HSA-975634 |
| Cellular Localisation | Apical Cell MembraneSingle-Pass Type I Membrane ProteinPresent In The Intestinal Brush Border Membranes |
| Alternative Antibody Names | Anti-Phospholipase B1 - Membrane-Associated antibodyAnti-Phospholipase B antibodyAnti-Hplb antibodyAnti-Lysophospholipase antibodyAnti-Phospholipase A2 antibodyAnti-Phospholipase B/Lipase antibodyAnti-Plb/Lip antibodyAnti-Triacylglycerol Lipase antibodyAnti-PLB1 antibodyAnti-PLB antibody |
Information sourced from Uniprot.org