| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PLB1 (1110-1415) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLB1 |
| Gene ID: |
151056 |
| Uniprot ID: |
PLB1_HUMAN |
| Immunogen Region: |
1110-1415 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1110-1415 of human PLB1 (NP_694566.4). |
| Immunogen Sequence: |
ARPNNSSDLPTSWRGLSWSI GGDGNLETHTTLPNILKKFN PYLLGFSTSTWEGTAGLNVA AEGARARDMPAQAWDLVERM KNSPDINLEKDWKLVTLFIG VNDLCHYCENPEAHLATEYV QHIQQALDILSEELPRAFVN VVEVMELASLYQGQGGKCAM LAAQNNCTCLRHSQSSLEKQ ELKKVNWNLQHGISSFSYWH QYTQREDFAVVVQPFFQNTL TPLNERGDTDLTFFSEDCF |
| Tissue Specificity | Expressed in the epidermis (at protein level). |
| Post Translational Modifications | Undergoes proteolytic cleavage in the ileum. |
| Function | Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border. |
| Protein Name | Phospholipase B1 - Membrane-AssociatedPhospholipase BHplbLysophospholipasePhospholipase A2Phospholipase B/LipasePlb/LipTriacylglycerol Lipase |
| Database Links | Reactome: R-HSA-1482788Reactome: R-HSA-975634 |
| Cellular Localisation | Apical Cell MembraneSingle-Pass Type I Membrane ProteinPresent In The Intestinal Brush Border Membranes |
| Alternative Antibody Names | Anti-Phospholipase B1 - Membrane-Associated antibodyAnti-Phospholipase B antibodyAnti-Hplb antibodyAnti-Lysophospholipase antibodyAnti-Phospholipase A2 antibodyAnti-Phospholipase B/Lipase antibodyAnti-Plb/Lip antibodyAnti-Triacylglycerol Lipase antibodyAnti-PLB1 antibodyAnti-PLB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
