Human placenta stained with anti-PLAP antibody using peroxidase-conjugate and DAB chromogen. Note the membrane staining of trophoblasts..

Anti-PLAP antibody (Full length) [ZM161] (STJ180369)

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STJ180369
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-PLAP (Full length) is suitable for use in Immunohistochemistry research applications.
Clonality : Monoclonal
Clone ID : ZM161
Conjugation: Unconjugated
Isotype: IgG2b/Kappa
Formulation: Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification: Affinity purified
Dilution Range: 1:100‐200
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol: PLAA
Gene ID: 9373
Uniprot ID: PLAP_HUMAN
Immunogen Region: Full length
Specificity: Positive control: Placenta
Immunogen: Recombinant full-length human ALPP protein
Function Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis.
Protein Name Phospholipase A-2-Activating Protein
Pla2p
Plap
Cellular Localisation Nucleus
Cytoplasm
Synapse
Recruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains
Alternative Antibody Names Anti-Phospholipase A-2-Activating Protein antibody
Anti-Pla2p antibody
Anti-Plap antibody
Anti-PLAA antibody
Anti-PLAP antibody

Information sourced from Uniprot.org

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