| Function | Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. For most substrates, PLA1 activity is much higher than PLA2 activity. Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs). Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Exhibits high phospholipase A1/2 activity and low N-acyltransferase activity. |
| Protein Name | Phospholipase A And Acyltransferase 2 Hras-Like Suppressor 2 |
| Database Links | Reactome: R-HSA-1482839 |
| Cellular Localisation | CytoplasmMembraneSingle-Pass Membrane ProteinExhibits A Granular Pattern In The Cytoplasm With Preferential Perinuclear Localization |
| Alternative Antibody Names | Anti-Phospholipase A And Acyltransferase 2 antibodyAnti-Hras-Like Suppressor 2 antibodyAnti-PLAAT2 antibodyAnti-HRASLS2 antibody |
Information sourced from Uniprot.org
