• Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using MYT1 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from HeLa cells, using MYT1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Myt 1 Polyclonal Antibody diluted at 1：2000

Anti-PKMYT1 antibody (49-98) (STJ94323)

SKU:
STJ94323

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase (49-98) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PKMYT1
Gene ID: 9088
Uniprot ID: PMYT1_HUMAN
Immunogen Region: 49-98
Specificity: Myt 1 Polyclonal Antibody detects endogenous levels of Myt 1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from human PKMYT1. AA range:49-98
Post Translational Modifications Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity.
Function Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
Protein Name Membrane-Associated Tyrosine- And Threonine-Specific Cdc2-Inhibitory Kinase
Myt1 Kinase
Database Links Reactome: R-HSA-156711
Reactome: R-HSA-69273
Reactome: R-HSA-69478
Cellular Localisation Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Golgi Apparatus Membrane
Alternative Antibody Names Anti-Membrane-Associated Tyrosine- And Threonine-Specific Cdc2-Inhibitory Kinase antibody
Anti-Myt1 Kinase antibody
Anti-PKMYT1 antibody
Anti-MYT1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance