| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | PIR |
| Gene ID: | 8544 |
| Uniprot ID: | PIR_HUMAN |
| Immunogen Region: | 1-290 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human PIR (NP_003653.1). |
| Immunogen Sequence: | MGSSKKVTLSVLSREQSEGV GARVRRSIGRPELKNLDPFL LFDEFKGGRPGGFPDHPHRG FETVSYLLEGGSMAHEDFCG HTGKMNPGDLQWMTAGRGIL HAEMPCSEEPAHGLQLWVNL RSSEKMVEPQYQELKSEEIP KPSKDGVTVAVISGEALGIK SKVYTRTPTLYLDFKLDPGA KHSQPIPKGWTSFIYTISGD VYIGPDDAQQKIEPHHTAVL GEGDSVQVENKDPKRSHFV |
| Tissue Specificity | Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver. |
| Function | Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). |
| Protein Name | PirinProbable Quercetin 2 -3-Dioxygenase PirProbable Quercetinase |
| Database Links | Reactome: R-HSA-8935690 |
| Cellular Localisation | NucleusCytoplasmPredominantly Localized In Dot-Like Subnuclear StructuresCytoplasmic Localization Of Pir Seems To Positively Correlate With Melanoma Progression |
| Alternative Antibody Names | Anti-Pirin antibodyAnti-Probable Quercetin 2 -3-Dioxygenase Pir antibodyAnti-Probable Quercetinase antibodyAnti-PIR antibody |
Information sourced from Uniprot.org
