| Function | Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate. Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation. |
| Protein Name | Type 2 Phosphatidylinositol 4 -5-Bisphosphate 4-PhosphataseType 2 Ptdins-4 -5-P2 4-PtasePtdins-4 -5-P2 4-Ptase IiTransmembrane Protein 55a |
| Database Links | |
| Cellular Localisation | Late Endosome MembraneMulti-Pass Membrane ProteinLysosome MembraneCytoplasmic VesiclePhagosome MembraneCell Membrane |
| Alternative Antibody Names | Anti-Type 2 Phosphatidylinositol 4 -5-Bisphosphate 4-Phosphatase antibodyAnti-Type 2 Ptdins-4 -5-P2 4-Ptase antibodyAnti-Ptdins-4 -5-P2 4-Ptase Ii antibodyAnti-Transmembrane Protein 55a antibodyAnti-PIP4P2 antibodyAnti-TMEM55A antibody |
Information sourced from Uniprot.org
