Anti-PIK3CA antibody (STJA0009923)

SKU:
STJA0009923

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phosphatidylinositol 4, 5-bisphosphate 3-kinase catalytic subunit alpha isoform is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PIK3CA
Gene ID: 5290
Uniprot ID: PK3CA_HUMAN
Specificity: This antibody detects endogenous levels of PIK3CA Phospho-Tyr317 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human PIK3CA Phospho-Tyr317
Function Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others. Plays a role in the positive regulation of phagocytosis and pinocytosis.
Protein Name Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform
Pi3-Kinase Subunit Alpha
Pi3k-Alpha
Pi3kalpha
Ptdins-3-Kinase Subunit Alpha
Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase 110 Kda Catalytic Subunit Alpha
Ptdins-3-Kinase Subunit P110-Alpha
P110alpha
Phosphoinositide 3-Kinase Alpha
Phosphoinositide-3-Kinase Catalytic Alpha Polypeptide
Serine/Threonine Protein Kinase Pik3ca
Database Links Reactome: R-HSA-109704
Reactome: R-HSA-112399
Reactome: R-HSA-114604
Reactome: R-HSA-1236382
Reactome: R-HSA-1250342
Reactome: R-HSA-1257604
Reactome: R-HSA-1433557
Reactome: R-HSA-1660499
Reactome: R-HSA-180292
Reactome: R-HSA-1839117
Reactome: R-HSA-186763
Reactome: R-HSA-1963642
Reactome: R-HSA-198203
Reactome: R-HSA-201556
Reactome: R-HSA-202424
Reactome: R-HSA-2029485
Reactome: R-HSA-210993
Reactome: R-HSA-2219530
Reactome: R-HSA-2424491
Reactome: R-HSA-2730905
Reactome: R-HSA-373753
Reactome: R-HSA-388841
Reactome: R-HSA-389357
Reactome: R-HSA-416476
Reactome: R-HSA-4420097
Reactome: R-HSA-512988
Reactome: R-HSA-5637810
Reactome: R-HSA-5654689
Reactome: R-HSA-5654695
Reactome: R-HSA-5654710
Reactome: R-HSA-5654720
Reactome: R-HSA-5655253
Reactome: R-HSA-5655291
Reactome: R-HSA-5655302
Reactome: R-HSA-5655332
Reactome: R-HSA-5673001
Reactome: R-HSA-6811558
Reactome: R-HSA-8851907
Reactome: R-HSA-8853659
Reactome: R-HSA-9009391
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9027276
Reactome: R-HSA-9028335
Reactome: R-HSA-912526
Reactome: R-HSA-912631
Reactome: R-HSA-9603381
Reactome: R-HSA-9607240
Reactome: R-HSA-9664565
Reactome: R-HSA-9665348
Reactome: R-HSA-9670439
Reactome: R-HSA-9673767
Reactome: R-HSA-9673770
Reactome: R-HSA-9680350
Reactome: R-HSA-9703465
Reactome: R-HSA-9703648
Reactome: R-HSA-9725370
Alternative Antibody Names Anti-Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform antibody
Anti-Pi3-Kinase Subunit Alpha antibody
Anti-Pi3k-Alpha antibody
Anti-Pi3kalpha antibody
Anti-Ptdins-3-Kinase Subunit Alpha antibody
Anti-Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase 110 Kda Catalytic Subunit Alpha antibody
Anti-Ptdins-3-Kinase Subunit P110-Alpha antibody
Anti-P110alpha antibody
Anti-Phosphoinositide 3-Kinase Alpha antibody
Anti-Phosphoinositide-3-Kinase Catalytic Alpha Polypeptide antibody
Anti-Serine/Threonine Protein Kinase Pik3ca antibody
Anti-PIK3CA antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance