Host: | Rabbit |
Applications: | WB/IHC |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Phosphatidylinositol 3-kinase catalytic subunit type 3 is suitable for use in Western Blot and Immunohistochemistry research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000 IHC-P 1:50-300 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | PIK3C3 |
Gene ID: | 5289 |
Uniprot ID: | PK3C3_HUMAN |
Specificity: | This antibody detects endogenous levels of PI 3 Kinase Class 3 Polyclonal Antibody at Human;Mouse;Rat;Predicted:Cow:PIG |
Immunogen: | Synthetic Peptide of PI 3 Kinase Class 3 |
Post Translational Modifications | Ubiquitinated via 'Lys-29'- and 'Lys-48'-linked ubiquitination by UBE3C, promoting its degradation. Deubiquitination by ZRANB1/TRABID promotes its stabilization, leading to autophagosome maturation. |
Function | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate.different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes. (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. |
Protein Name | Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 Pi3-Kinase Type 3 Pi3k Type 3 Ptdins-3-Kinase Type 3 Phosphatidylinositol 3-Kinase P100 Subunit Phosphoinositide-3-Kinase Class 3 Hvps34 |
Database Links | Reactome: R-HSA-109704 Reactome: R-HSA-1632852 Reactome: R-HSA-1660514 Reactome: R-HSA-1660516 Reactome: R-HSA-1660517 Reactome: R-HSA-168138 Reactome: R-HSA-5668599 Reactome: R-HSA-9679504 Reactome: R-HSA-9694676 Reactome: R-HSA-9705671 Reactome: R-HSA-983170 |
Cellular Localisation | Midbody Late Endosome Cytoplasmic Vesicle Autophagosome As Component Of The Pi3k Complex I Localized To Pre-Autophagosome Structures As Component Of The Pi3k Complex Ii Localized Predominantly To Endosomes Localizes Also To Discrete Punctae Along The Ciliary Axoneme And To The Base Of The Ciliary Axoneme |
Alternative Antibody Names | Anti-Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 antibody Anti-Pi3-Kinase Type 3 antibody Anti-Pi3k Type 3 antibody Anti-Ptdins-3-Kinase Type 3 antibody Anti-Phosphatidylinositol 3-Kinase P100 Subunit antibody Anti-Phosphoinositide-3-Kinase Class 3 antibody Anti-Hvps34 antibody Anti-PIK3C3 antibody Anti-VPS34 antibody |
Information sourced from Uniprot.org