| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Polymeric immunoglobulin receptor is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PIGR |
| Gene ID: |
5284 |
| Uniprot ID: |
PIGR_HUMAN |
| Specificity: |
PIGR Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Function | Polymeric immunoglobulin receptor: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. Secretory component: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells. |
| Protein Name | Polymeric Immunoglobulin ReceptorPigrPoly-Ig ReceptorHepatocellular Carcinoma-Associated Protein Tb6 Cleaved Into - Secretory Component |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Polymeric Immunoglobulin Receptor: Cell MembraneSingle-Pass Type I Membrane ProteinSecretory Component: Secreted |
| Alternative Antibody Names | Anti-Polymeric Immunoglobulin Receptor antibodyAnti-Pigr antibodyAnti-Poly-Ig Receptor antibodyAnti-Hepatocellular Carcinoma-Associated Protein Tb6 Cleaved Into - Secretory Component antibodyAnti-PIGR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
