| Function | DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. |
| Protein Name | Atp-Dependent Dna Helicase Pif1Dna Repair And Recombination Helicase Pif1Pif1/Rrm3 Dna Helicase-Like Protein |
| Database Links | Reactome: R-HSA-171319 |
| Cellular Localisation | NucleusIsoform 4: Mitochondrion |
| Alternative Antibody Names | Anti-Atp-Dependent Dna Helicase Pif1 antibodyAnti-Dna Repair And Recombination Helicase Pif1 antibodyAnti-Pif1/Rrm3 Dna Helicase-Like Protein antibodyAnti-PIF1 antibodyAnti-C15orf20 antibody |
Information sourced from Uniprot.org
