Host: | Rabbit |
Applications: | ELISA/IP/WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-PICK1 (330-380) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
Purification: | Affinity Purified |
Concentration: | 0.5-1.5 µg/µl |
Dilution Range: | WB: 1:500-1:5, 000 ELISA: 1:50, 000 IP: 1:200 |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | PICK1 |
Gene ID: | 9463 |
Uniprot ID: | PICK1_HUMAN |
Immunogen Region: | 330-380 |
Immunogen: | Synthetic peptide taken within amino acid region 330-380 on human PRKCA-binding protein/PICK1 protein. |
Post Translational Modifications | Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors. Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD). |
Function | Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex.the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. |
Protein Name | Prkca-Binding Protein Protein Interacting With C Kinase 1 Protein Kinase C-Alpha-Binding Protein |
Database Links | Reactome: R-HSA-202733 Reactome: R-HSA-416993 |
Cellular Localisation | Cytoplasm Perinuclear Region Membrane Peripheral Membrane Protein Lipid-Anchor Postsynaptic Density Synapse Synaptosome Cytoskeleton Also Membrane-Associated Present At Excitatory Synapses |
Alternative Antibody Names | Anti-Prkca-Binding Protein antibody Anti-Protein Interacting With C Kinase 1 antibody Anti-Protein Kinase C-Alpha-Binding Protein antibody Anti-PICK1 antibody Anti-PRKCABP antibody |
Information sourced from Uniprot.org