Anti-Phospholipase A2 Activator Protein antibody [R01-1N8] (STJA0037364)

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STJA0037364
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Host: Rabbit
Applications: WB/IHC-P/ICC/IF/IP
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal anti-Phospholipase A2 Activator Protein for use in WB, IHC-P, ICC, IF and IP in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : R01-1N8
Conjugation: Unconjugated
Isotype: IgG
Formulation: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification: Affinity Purified
Dilution Range: WB 1:500-1:1000
IHC 1:50-1:100
IF 1:50-1:200
IP 1:50
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: PLAA
Gene ID: 9373
Uniprot ID: PLAP_HUMAN
Immunogen: A synthesized peptide derived from human PLAP
Function Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis.
Protein Name Phospholipase A-2-Activating Protein
Pla2p
Plap
Database Links
Cellular Localisation Nucleus
Cytoplasm
Synapse
Recruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains
Alternative Antibody Names Anti-Phospholipase A-2-Activating Protein antibody
Anti-Pla2p antibody
Anti-Plap antibody
Anti-PLAA antibody
Anti-PLAP antibody

Information sourced from Uniprot.org

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