Anti-Phospho-WASL-Ser-484/Ser-485 antibody (STJA0005647)

SKU:
STJA0005647-100

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Host: Rabbit
Applications: WB/ICC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-N-WASP-Ser-484/Ser-485 is suitable for use in Western Blot and Immunocytochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Antigen Affinity Purified
Dilution Range: WB 1:1000
IHC
ICC 1:50
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: WASL
Gene ID: 8976
Uniprot ID: WASL_HUMAN
Specificity: This antibody was cross-adsorbed to unphosphorylated-N-WASP (S484/S485) peptide then affinity purified using phospho-N-WASP (S484/S485) peptide. The antibody detects a 63 kDa* protein corresponding to the molecular mass of phosphorylated WASP on SDS-
Immunogen: Phospho-N-WASP (S484/S485) synthetic peptide (coupled to KLH) corresponding to amino acid residues around serine 484 and 485 of human N-WASP. The human WASP sequence has a similar peptide sequence surrounding serine 483 and 484.
Function Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis. Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear.
Protein Name Actin Nucleation-Promoting Factor Wasl
Neural Wiskott-Aldrich Syndrome Protein
N-Wasp
Database Links Reactome: R-HSA-2029482
Reactome: R-HSA-203641
Reactome: R-HSA-373753
Reactome: R-HSA-3928662
Reactome: R-HSA-418885
Reactome: R-HSA-5663213
Reactome: R-HSA-8856828
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013406
Reactome: R-HSA-9013409
Reactome: R-HSA-9013424
Reactome: R-HSA-9664422
Cellular Localisation Cytoplasm
Cytoskeleton
Nucleus
Preferentially Localized In The Cytoplasm When Phosphorylated And In The Nucleus When Unphosphorylated
Exported From The Nucleus By An Nuclear Export Signal (Nes)-Dependent Mechanism To The Cytoplasm
Alternative Antibody Names Anti-Actin Nucleation-Promoting Factor Wasl antibody
Anti-Neural Wiskott-Aldrich Syndrome Protein antibody
Anti-N-Wasp antibody
Anti-WASL antibody

Information sourced from Uniprot.org

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