Anti-Phospho-Vav2-Tyr-142 antibody (STJA0041440)

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STJA0041440-100
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Host: Rabbit
Applications: ELISA/WB/ICC
Reactivity: Chicken/Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal anti-Phospho-Vav2-Tyr-142 for use in ELISA, WB and ICC in Chicken, Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Antigen Affinity Purified
Dilution Range: WB 1:1000
ICC 1:100
Storage Instruction: Storage at-20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at-20°C.
Gene Symbol: Vav2
Gene ID: 22325
Uniprot ID: VAV2_MOUSE
Specificity: This antibody was cross-adsorbed to unphosphorylated Vav2 (Tyr-142) peptide before affinity purification using phospho-Vav2 (Tyr-142) peptide (without carrier). The antibody detects a 100 kDa* band corresponding to Vav on SDS-PAGE immunoblots of huma
Immunogen: Phospho-Vav2 (Tyr-142) synthetic peptide (coupled to KLH) corresponding to amino acid residues surrounding Tyr-142 in mouse Vav2. This sequence has high homology with similar regions in rat and human Vav2, and has significant homology to the conserve
Immunogen Sequence: Mouse
Post Translational Modifications Phosphorylated on tyrosine residues in response to FGR activation.
Function Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
Protein Name Guanine Nucleotide Exchange Factor Vav2
Vav-2
Database Links Reactome: R-MMU-114604
Reactome: -MMU-193648
Reactome: -MMU-2029482
Reactome: -MMU-2424491
Reactome: -MMU-2871796
Reactome: -MMU-2871809
Reactome: -MMU-3928665
Reactome: -MMU-416482
Reactome: -MMU-4420097
Reactome: -MMU-445144
Reactome: -MMU-5218920
Reactome: -MMU-8980692
Reactome: -MMU-9013026
Reactome: -MMU-9013106
Reactome: -MMU-9013148
Reactome: -MMU-9013149
Reactome: -MMU-9013404
Reactome: -MMU-9013408
Reactome: -MMU-9013423
Reactome: -MMU-9748787
Cellular Localisation
Alternative Antibody Names Anti-Guanine Nucleotide Exchange Factor Vav2 antibody
Anti-Vav-2 antibody
Anti-Vav2 antibody

Information sourced from Uniprot.org