Anti-Phospho-VAV1-Tyr174 antibody (141-190 aa) (STJ90434)

SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human VAV1 around the phosphorylation site of Tyr174 at the amino acid range 141-190
STJ90434
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General Information

Short DescriptionRabbit polyclonal anti-Phospho-Proto-oncogene vav-Tyr174 (141-190 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
ApplicationsWB/ELISA
HostRabbit
ReactivityHuman/Mouse/Rat
NoteSTRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Product Properties

ClonalityPolyclonal
IsotypeIgG
ConjugationUnconjugated
Concentration1 mg/mL
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution RangeWB 1:500-1:2000
ELISA 1:10000
FormulationLiquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage InstructionStore at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Target Information

Gene SymbolVAV1
Gene ID7409
Uniprot IDVAV_HUMAN
ImmunogenThe antiserum was produced against synthesized peptide derived from the human VAV1 around the phosphorylation site of Tyr174 at the amino acid range 141-190
Immunogen Region141-190 aa
SpecificityPhospho-Vav1 (Y174) Polyclonal Antibody detects endogenous levels of Vav1 protein only when phosphorylated at Y174.

Additional Info

Post Translational Modifications Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS). Phosphorylated by FYN.
Function Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
Protein Name Proto-Oncogene Vav
Database Links Reactome: R-HSA-114604
Reactome: R-HSA-1257604
Reactome: R-HSA-1433557
Reactome: R-HSA-193648
Reactome: R-HSA-2029482
Reactome: R-HSA-2219530
Reactome: R-HSA-2871796
Reactome: R-HSA-2871809
Reactome: R-HSA-389359
Reactome: R-HSA-416482
Reactome: R-HSA-4420097
Reactome: R-HSA-512988
Reactome: R-HSA-5218920
Reactome: R-HSA-6811558
Reactome: R-HSA-8980692
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013408
Reactome: R-HSA-9027284
Reactome: R-HSA-912631
Reactome: R-HSA-9664422
Reactome: R-HSA-9679191
Reactome: R-HSA-9748787
Reactome: R-HSA-983695
Cellular Localisation
Alternative Antibody Names Anti-Proto-Oncogene Vav antibody
Anti-VAV1 antibody
Anti-VAV antibody

Information sourced from Uniprot.org

Citations

Product Review