| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Tryptophan 5-hydroxylase 1-Ser58 (26-75 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TPH1 |
| Gene ID: | 7166 |
| Uniprot ID: | TPH1_HUMAN |
| Immunogen Region: | 26-75 aa |
| Specificity: | Phospho-TPH1 (S58) Polyclonal Antibody detects endogenous levels of TPH1 protein only when phosphorylated at S58. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Tryptophan Hydroxylase around the phosphorylation site of Ser58 at the amino acid range 26-75 |
| Post Translational Modifications | Ubiquitinated, leading to its degradation by the proteasome. Ubiquitinated is triggered by phosphorylation. Phosphorylated.triggering degradation by the proteasome. |
| Function | Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis. |
| Protein Name | Tryptophan 5-Hydroxylase 1 Tryptophan 5-Monooxygenase 1 |
| Database Links | Reactome: R-HSA-209931 Reactome: R-HSA-9031628 |
| Alternative Antibody Names | Anti-Tryptophan 5-Hydroxylase 1 antibody Anti-Tryptophan 5-Monooxygenase 1 antibody Anti-TPH1 antibody Anti-TPH antibody Anti-TPRH antibody Anti-TRPH antibody |
Information sourced from Uniprot.org