• Western blot of rat brainstem lysate showing specific immunolabeling of the ~55 kDa TPH protein phosphorylated at Ser260 in lane one (-). Phosphospecificity is shown in the second lane (P) where immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide (NP) , shown in the third lane.

Anti-Phospho-TPH1-Ser260 antibody (STJA0003814)

SKU:
STJA0003814-100

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Host: Rabbit
Applications: WB
Reactivity: Human/Rat/Bovine/Canine/Chicken/Mouse/Zebrafish
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Tryptophan Hydroxylase-Ser260 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Tph1
Gene ID: 24848
Uniprot ID: TPH1_RAT
Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser260 conjugated to KLH.
Post Translational Modifications Ubiquitinated, leading to its degradation by the proteasome. Ubiquitinated is triggered by phosphorylation. Phosphorylated.triggering degradation by the proteasome.
Function Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.
Protein Name Tryptophan 5-Hydroxylase 1
Tryptophan 5-Monooxygenase 1
Database Links Reactome: R-RNO-209931
Alternative Antibody Names Anti-Tryptophan 5-Hydroxylase 1 antibody
Anti-Tryptophan 5-Monooxygenase 1 antibody
Anti-Tph1 antibody
Anti-Tph antibody

Information sourced from Uniprot.org

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