Anti-Phospho-TGFB1I1-Tyr60 antibody (STJA0009949)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Hic-5 (Phospho-Tyr60)
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Transforming growth factor beta-1-induced transcript 1 protein-Tyr60 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TGFB1I1 |
| Gene ID | 7041 |
| Uniprot ID | TGFI1_HUMAN |
| Immunogen | Synthesized peptide derived from human Hic-5 (Phospho-Tyr60) |
| Specificity | This antibody detects endogenous levels of Hic-5 (Phospho-Tyr60) at Human, Mouse, Rat |
Additional Info
| Tissue Specificity | Expressed in platelets, smooth muscle and prostate stromal cells (at protein level). |
| Post Translational Modifications | Phosphorylated by gonadotropin-releasing hormone-activated SRC. |
| Function | Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. |
| Protein Name | Transforming Growth Factor Beta-1-Induced Transcript 1 ProteinAndrogen Receptor Coactivator 55 Kda ProteinAndrogen Receptor-Associated Protein Of 55 KdaHydrogen Peroxide-Inducible Clone 5 ProteinHic-5 |
| Database Links | |
| Cellular Localisation | Cell JunctionFocal AdhesionNucleus MatrixCytoplasmCytoskeletonAssociated With The Actin CytoskeletonColocalizes With Stress Fibers |
| Alternative Antibody Names | Anti-Transforming Growth Factor Beta-1-Induced Transcript 1 Protein antibodyAnti-Androgen Receptor Coactivator 55 Kda Protein antibodyAnti-Androgen Receptor-Associated Protein Of 55 Kda antibodyAnti-Hydrogen Peroxide-Inducible Clone 5 Protein antibodyAnti-Hic-5 antibodyAnti-TGFB1I1 antibodyAnti-ARA55 antibody |
Information sourced from Uniprot.org