| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat/Canine/Chicken/Finch/Xenopus/Zebrafish |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-TAO2-Ser181 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Purification: |
This antibody was antigen affinity purified from pooled serum. |
| Dilution Range: |
WB 1:1000IHCICCIP |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TAOK2 |
| Gene ID: |
9344 |
| Uniprot ID: |
TAOK2_HUMAN |
| Immunogen: |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser181 conjugated to KLH. |
| Tissue Specificity | Ubiquitously expressed, with a higher level of expression in testis and brain. |
| Post Translational Modifications | Isoforms 1 and 2 are autophosphorylated. C-terminal cleavage of isoform 1 and subsequent nuclear localization requires CASP9 activity. Autophosphorylated. Phosphorylated by ATM. Isoform 2: Phosphorylated on Ser-1031 by MAPK14. This phosphorylation is required PCDH8 for endocytosis. |
| Function | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. |
| Protein Name | Serine/Threonine-Protein Kinase Tao2Kinase From Chicken Homolog CHkfc-CProstate-Derived Sterile 20-Like Kinase 1Psk-1Psk1Prostate-Derived Ste20-Like Kinase 1Thousand And One Amino Acid Protein Kinase 2 |
| Cellular Localisation | Cytoplasmic Vesicle MembraneMulti-Pass Membrane ProteinCytoplasmCytoskeletonNucleusCatalytically Active Full-Length Phosphorylated Isoform 1 Localizes To Microtubules In The Cytoplasm Predominantly On Microtubule Cables Positioned Around The NucleusA C-Terminally Truncated Form Of Isoform 1 Is Present In The NucleusIsoform 2 And Kinase-DefectiveAs Well As Full-Length Isoform 1 Are Excluded From The NucleusIsoform 2: Cell ProjectionDendriteIn DendritesColocalizes With Pcdh8 |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Tao2 antibodyAnti-Kinase From Chicken Homolog C antibodyAnti-Hkfc-C antibodyAnti-Prostate-Derived Sterile 20-Like Kinase 1 antibodyAnti-Psk-1 antibodyAnti-Psk1 antibodyAnti-Prostate-Derived Ste20-Like Kinase 1 antibodyAnti-Thousand And One Amino Acid Protein Kinase 2 antibodyAnti-TAOK2 antibodyAnti-KIAA0881 antibodyAnti-MAP3K17 antibodyAnti-PSK antibodyAnti-PSK1 antibodyAnti-UNQ2971 antibodyAnti-PRO7431 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
