Anti-Phospho-STMN1-Ser25 antibody (9-58 aa) (STJ90358)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Stathmin 1 around the phosphorylation site of Ser24 at the amino acid range 9-58
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Stathmin-Ser25 (9-58 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STMN1 |
| Gene ID | 3925 |
| Uniprot ID | STMN1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Stathmin 1 around the phosphorylation site of Ser24 at the amino acid range 9-58 |
| Immunogen Region | 9-58 aa |
| Specificity | Phospho-Op18 (S25) Polyclonal Antibody detects endogenous levels of Op18 protein only when phosphorylated at S25. |
Additional Info
| Post Translational Modifications | Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization. Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. |
| Function | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear. |
| Protein Name | StathminLeukemia-Associated Phosphoprotein P18MetablastinOncoprotein 18Op18Phosphoprotein P19Pp19ProsolinProtein Pr22Pp17 |
| Database Links | Reactome: R-HSA-1251985 |
| Cellular Localisation | CytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Stathmin antibodyAnti-Leukemia-Associated Phosphoprotein P18 antibodyAnti-Metablastin antibodyAnti-Oncoprotein 18 antibodyAnti-Op18 antibodyAnti-Phosphoprotein P19 antibodyAnti-Pp19 antibodyAnti-Prosolin antibodyAnti-Protein Pr22 antibodyAnti-Pp17 antibodyAnti-STMN1 antibodyAnti-C1orf215 antibodyAnti-LAP18 antibodyAnti-OP18 antibody |
Information sourced from Uniprot.org