| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Stathmin-Ser16 (5-54 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | STMN1 |
| Gene ID: | 3925 |
| Uniprot ID: | STMN1_HUMAN |
| Immunogen Region: | 5-54 aa |
| Specificity: | Phospho-Op18 (S16) Polyclonal Antibody detects endogenous levels of Op18 protein only when phosphorylated at S16. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Stathmin 1 around the phosphorylation site of Ser15 at the amino acid range 5-54 |
| Post Translational Modifications | Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization. Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. |
| Function | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear. |
| Protein Name | Stathmin Leukemia-Associated Phosphoprotein P18 Metablastin Oncoprotein 18 Op18 Phosphoprotein P19 Pp19 Prosolin Protein Pr22 Pp17 |
| Database Links | Reactome: R-HSA-1251985 |
| Cellular Localisation | Cytoplasm Cytoskeleton |
| Alternative Antibody Names | Anti-Stathmin antibody Anti-Leukemia-Associated Phosphoprotein P18 antibody Anti-Metablastin antibody Anti-Oncoprotein 18 antibody Anti-Op18 antibody Anti-Phosphoprotein P19 antibody Anti-Pp19 antibody Anti-Prosolin antibody Anti-Protein Pr22 antibody Anti-Pp17 antibody Anti-STMN1 antibody Anti-C1orf215 antibody Anti-LAP18 antibody Anti-OP18 antibody |
Information sourced from Uniprot.org