| Short Description : | Rabbit polyclonal anti-Phospho-Lupus La protein-Ser366 (341-390 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SSB |
| Gene ID: | 6741 |
| Uniprot ID: | LA_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human SSB around the phosphorylation site of Ser366 at the amino acid range 341-390 |
| Immunogen Region: | 341-390 aa |
| Specificity: | Phospho-SSB (S366) Polyclonal Antibody detects endogenous levels of SSB protein only when phosphorylated at S366. |
| Function | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation. |
| Protein Name | Lupus La ProteinLa AutoantigenLa RibonucleoproteinSjoegren Syndrome Type B AntigenSs-B |
| Database Links | Reactome: R-HSA-73980Reactome: R-HSA-749476 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lupus La Protein antibodyAnti-La Autoantigen antibodyAnti-La Ribonucleoprotein antibodyAnti-Sjoegren Syndrome Type B Antigen antibodyAnti-Ss-B antibodyAnti-SSB antibody |
Information sourced from Uniprot.org
