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Anti-Phospho-SMC3-Ser1083 antibody (STJ193208)

Immunohistochemical analysis of paraffin-embedded human brain tumor. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-Phospho-SMC3-Ser1083 antibody (STJ193208)

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STJ193208

£46.00 - £226.00

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General Information
Product Properties
Target Information
Additional Info
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Host:	Rabbit
Applications:	IHC/IF/WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Phospho-Structural maintenance of chromosomes protein 3-Ser1083 is suitable for use in Immunohistochemistry, Immunofluorescence and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	IHC-P 1:50-200 WB 1:500-2000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	SMC3
Gene ID:	9126
Uniprot ID:	SMC3_HUMAN
Specificity:	This antibody detects endogenous phospho levels of Bamacan (Phospho-Ser1083) at Human:S1083, Mouse:S1083, Rat:S1083
Immunogen:	Synthesized peptide derived from the human Bamacan (Phospho-Ser1083)

Function	Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
Protein Name	Structural Maintenance Of Chromosomes Protein 3 Smc Protein 3 Smc-3 Basement Membrane-Associated Chondroitin Proteoglycan Bamacan Chondroitin Sulfate Proteoglycan 6 Chromosome-Associated Polypeptide Hcap
Database Links	Reactome: R-HSA-1221632 Reactome: R-HSA-2467813 Reactome: R-HSA-2468052 Reactome: R-HSA-2470946 Reactome: R-HSA-2500257 Reactome: R-HSA-3108214 Reactome: R-HSA-9018519
Cellular Localisation	Nucleus Chromosome Centromere Associates With Chromatin Before Prophase It Is Scattered Along Chromosome Arms During Prophase Most Of Cohesin Complexes Dissociate From Chromatin Probably Because Of Phosphorylation By Plk Except At Centromeres Where Cohesin Complexes Remain At Anaphase The Rad21 Subunit Of The Cohesin Complex Is Cleaved Leading To The Dissociation Of The Complex From Chromosomes Allowing Chromosome Separation The Phosphorylated Form At Ser-1083 Is Preferentially Associated With Unsynapsed Chromosomal Regions
Alternative Antibody Names	Anti-Structural Maintenance Of Chromosomes Protein 3 antibody Anti-Smc Protein 3 antibody Anti-Smc-3 antibody Anti-Basement Membrane-Associated Chondroitin Proteoglycan antibody Anti-Bamacan antibody Anti-Chondroitin Sulfate Proteoglycan 6 antibody Anti-Chromosome-Associated Polypeptide antibody Anti-Hcap antibody Anti-SMC3 antibody Anti-BAM antibody Anti-BMH antibody Anti-CSPG6 antibody Anti-SMC3L1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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