Anti-Phospho-RPH3A-Ser237 antibody (203-252 aa) (STJ91051)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Rabphilin 3A around the phosphorylation site of Ser237 at the amino acid range 203-252
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Rabphilin-3A-Ser237 (203-252 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RPH3A |
| Gene ID | 22895 |
| Uniprot ID | RP3A_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Rabphilin 3A around the phosphorylation site of Ser237 at the amino acid range 203-252 |
| Immunogen Region | 203-252 aa |
| Specificity | Phospho-Rabphilin-3A (S237) Polyclonal Antibody detects endogenous levels of Rabphilin-3A protein only when phosphorylated at S237. |
Additional Info
| Function | Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone. |
| Protein Name | Rabphilin-3aExophilin-1 |
| Database Links | |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneCell ProjectionDendritic SpinePostsynaptic Cell MembraneMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Rabphilin-3a antibodyAnti-Exophilin-1 antibodyAnti-RPH3A antibodyAnti-KIAA0985 antibody |
Information sourced from Uniprot.org