• Immunohistochemistry analysis of paraffin-embedded human brain, using Rabphilin 3A (Phospho-Ser237) Antibody. The picture on the right is blocked with the phospho peptide.
  • Western blot analysis of lysates from RAW264.7 cells treated with Calyculin 100nM 15', using Rabphilin 3A (Phospho-Ser237) Antibody. The lane on the right is blocked with the phospho peptide.
  • Immunofluorescence analysis of HeLa cells, using Rabphilin 3A (Phospho-Ser237) Antibody. The picture on the right is blocked with the phospho peptide.

Anti-Phospho-RPH3A-Ser237 antibody (203-252 aa) (STJ91051)

SKU:
STJ91051

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Rabphilin-3A-Ser237 (203-252 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RPH3A
Gene ID: 22895
Uniprot ID: RP3A_HUMAN
Immunogen Region: 203-252 aa
Specificity: Phospho-Rabphilin-3A (S237) Polyclonal Antibody detects endogenous levels of Rabphilin-3A protein only when phosphorylated at S237.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Rabphilin 3A around the phosphorylation site of Ser237 at the amino acid range 203-252
Function Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone.
Protein Name Rabphilin-3a
Exophilin-1
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle
Synaptic Vesicle Membrane
Cell Projection
Dendritic Spine
Postsynaptic Cell Membrane
Membrane
Peripheral Membrane Protein
Alternative Antibody Names Anti-Rabphilin-3a antibody
Anti-Exophilin-1 antibody
Anti-RPH3A antibody
Anti-KIAA0985 antibody

Information sourced from Uniprot.org

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