| Short Description : | Rabbit polyclonal anti-Phospho-Rabphilin-3A-Ser237 (203-252 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RPH3A |
| Gene ID: | 22895 |
| Uniprot ID: | RP3A_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Rabphilin 3A around the phosphorylation site of Ser237 at the amino acid range 203-252 |
| Immunogen Region: | 203-252 aa |
| Specificity: | Phospho-Rabphilin-3A (S237) Polyclonal Antibody detects endogenous levels of Rabphilin-3A protein only when phosphorylated at S237. |
| Function | Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Also plays a role in the exocytosis of arginine vasopressin hormone. |
| Protein Name | Rabphilin-3aExophilin-1 |
| Database Links | |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneCell ProjectionDendritic SpinePostsynaptic Cell MembraneMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Rabphilin-3a antibodyAnti-Exophilin-1 antibodyAnti-RPH3A antibodyAnti-KIAA0985 antibody |
Information sourced from Uniprot.org
