| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-Inactive tyrosine-protein kinase PRAG1-Tyr413 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PRAG1 |
| Gene ID: |
157285 |
| Uniprot ID: |
PRAG1_HUMAN |
| Specificity: |
Phospho-Pragmin (Y413) Polyclonal Antibody detects endogenous levels of Pragmin protein only when phosphorylated at Y413. |
| Immunogen: |
Synthesized phospho-peptide around the phosphorylation site of human Pragmin (phospho Tyr413) |
| Function | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth. Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism. Acts as a critical coactivator of Notch signaling. |
| Protein Name | Inactive Tyrosine-Protein Kinase Prag1Peak1-Related Kinase-Activating Pseudokinase 1PragminSugen Kinase 223Sgk223 |
| Database Links | Reactome: R-HSA-9696270 |
| Cellular Localisation | CytoplasmCell JunctionFocal AdhesionNucleusColocalized With Notch1 In The Nucleus |
| Alternative Antibody Names | Anti-Inactive Tyrosine-Protein Kinase Prag1 antibodyAnti-Peak1-Related Kinase-Activating Pseudokinase 1 antibodyAnti-Pragmin antibodyAnti-Sugen Kinase 223 antibodyAnti-Sgk223 antibodyAnti-PRAG1 antibodyAnti-SGK223 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
