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Anti-Phospho-PLCB3-S1105 antibody (STJ11100978)

Western blot analysis of extracts of HeLa cells, using Phospho-PLCB3-S1105 antibody (STJ11100978) at 1:1000 dilution. HeLa cells were treated by PMA/TPA (200nM) for 15 minutes after serum-starvation overnight. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Basic Kit. Exposure time: 10s.
Western blot analysis of lysates from HeLa cells, using Phospho-PLC beta 3 (PLCB3) -S1105 Rabbit polyclonal antibody (STJ11100978) at 1:1000 dilution. HeLa cells were treated by PMA/TPA (200nM) for 15 minutes after serum-starvation overnight. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% BSA. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-Phospho-PLCB3-S1105 antibody (STJ11100978)

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STJ11100978

£129.50 - £642.50

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General Information
Product Properties
Target Information
Additional Info
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Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification:	Affinity purification
Concentration:	Lot specific
Dilution Range:	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	PLCB3
Gene ID:	5331
Uniprot ID:	PLCB3_HUMAN
Specificity:	A synthetic phosphorylated peptide around S1105 of human PLC beta 3 (PLCB3) (NP_000923.1).
Immunogen Sequence:	HNSIS

Function	Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses.
Protein Name	1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-3 Phosphoinositide Phospholipase C-Beta-3 Phospholipase C-Beta-3 Plc-Beta-3
Database Links	Reactome: R-HSA-112043 Reactome: R-HSA-1855204 Reactome: R-HSA-399997 Reactome: R-HSA-4086398 Reactome: R-HSA-416476 Reactome: R-HSA-418217 Reactome: R-HSA-434316 Reactome: R-HSA-500657
Cellular Localisation	Cytoplasm Membrane Nucleus And Particulate Fractions
Alternative Antibody Names	Anti-1-Phosphatidylinositol 4 -5-Bisphosphate Phosphodiesterase Beta-3 antibody Anti-Phosphoinositide Phospholipase C-Beta-3 antibody Anti-Phospholipase C-Beta-3 antibody Anti-Plc-Beta-3 antibody Anti-PLCB3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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