| Tissue Specificity | Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls. |
| Post Translational Modifications | Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones. |
| Function | Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. |
| Protein Name | Astrocytic Phosphoprotein Pea-1515 Kda Phosphoprotein Enriched In AstrocytesPhosphoprotein Enriched In DiabetesPed |
| Database Links | Reactome: R-HSA-112409Reactome: R-HSA-5673001 |
| Cellular Localisation | CytoplasmAssociated With Microtubules |
| Alternative Antibody Names | Anti-Astrocytic Phosphoprotein Pea-15 antibodyAnti-15 Kda Phosphoprotein Enriched In Astrocytes antibodyAnti-Phosphoprotein Enriched In Diabetes antibodyAnti-Ped antibodyAnti-PEA15 antibody |
Information sourced from Uniprot.org
