• Western Blot analysis of Hela using primary antibody at 1:1000 dilution 4°C, overnight. Secondary antibody (STJS000791) was diluted at 1:10000 25°C, 1. 5hours

Anti-Phospho-PDE3A-Ser312 antibody (STJA0009951)

SKU:
STJA0009951

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-cGMP-inhibited 3 NA, 5 cyclic phosphodiesterase 3A-Ser312 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PDE3A
Gene ID: 5139
Uniprot ID: PDE3A_HUMAN
Specificity: This antibody detects endogenous levels of PDE3A (Phospho-Ser312) at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human PDE3A (Phospho-Ser312)
Function Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has also activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling.
Protein Name Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a
Cyclic Gmp-Inhibited Phosphodiesterase A
Cgi-Pde A
Cgmp-Inhibited Camp Phosphodiesterase
Cgi-Pde
Database Links Reactome: R-HSA-418555
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Cytoplasm
Cytosol
Alternative Antibody Names Anti-Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a antibody
Anti-Cyclic Gmp-Inhibited Phosphodiesterase A antibody
Anti-Cgi-Pde A antibody
Anti-Cgmp-Inhibited Camp Phosphodiesterase antibody
Anti-Cgi-Pde antibody
Anti-PDE3A antibody

Information sourced from Uniprot.org

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