Host: | Rabbit |
Applications: | CM/ELISA/ICC/IF/IHC/IP/WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Phospho-PDE11A (75-125) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
Purification: | Affinity Purified |
Concentration: | 0.69 µg/µl |
Dilution Range: | WB: 1:500 ELISA: 1:10, 000 IP: 1:250 IHC: 1:250 ICC: 1:250 IF: 1:250 |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | PDE11A |
Gene ID: | 50940 |
Uniprot ID: | PDE11_HUMAN |
Immunogen Region: | 75-125 |
Immunogen: | Synthetic peptide taken within amino acid region 75-125 on PDE11A protein. Phosphorylated Ser 117. |
Tissue Specificity | Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex. |
Function | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. |
Protein Name | Dual 3' -5'-Cyclic-Amp And -Gmp Phosphodiesterase 11a Camp And Cgmp Phosphodiesterase 11a |
Database Links | Reactome: R-HSA-418457 Reactome: R-HSA-418555 |
Cellular Localisation | Cytoplasm Cytosol |
Alternative Antibody Names | Anti-Dual 3' -5'-Cyclic-Amp And -Gmp Phosphodiesterase 11a antibody Anti-Camp And Cgmp Phosphodiesterase 11a antibody Anti-PDE11A antibody |
Information sourced from Uniprot.org