| Tissue Specificity | Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. |
| Function | Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development. Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration. |
| Protein Name | Alpha-ParvinActopaxinCh-IlkbpCalponin-Like Integrin-Linked Kinase-Binding ProteinMatrix-Remodeling-Associated Protein 2 |
| Database Links | Reactome: R-HSA-446343Reactome: R-HSA-446353Reactome: R-HSA-446388 |
| Cellular Localisation | Cell JunctionFocal AdhesionCell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonMyofibrilSarcomereZ Line |
| Alternative Antibody Names | Anti-Alpha-Parvin antibodyAnti-Actopaxin antibodyAnti-Ch-Ilkbp antibodyAnti-Calponin-Like Integrin-Linked Kinase-Binding Protein antibodyAnti-Matrix-Remodeling-Associated Protein 2 antibodyAnti-PARVA antibodyAnti-MXRA2 antibody |
Information sourced from Uniprot.org
