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Anti-Phospho-NOS3-Ser1179 antibody (STJ193218)

Western Blot analysis of K562 cells, cell treated or untreated by EGF 20ng/ml 30'. primary Antibody was diluted at 1:1000. Secondary antibody (catalog#:STJS000791 was diluted at 1:10000

Anti-Phospho-NOS3-Ser1179 antibody (STJ193218)

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STJ193218

£46.00 - £226.00

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General Information
Product Properties
Target Information
Additional Info
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Host:	Rabbit
Applications:	IHC/IF/WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Phospho-Nitric oxide synthase 3-Ser1179 is suitable for use in Immunohistochemistry, Immunofluorescence and Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	IHC-P 1:50-200 WB 1:500-2000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	NOS3
Gene ID:	4846
Uniprot ID:	NOS3_HUMAN
Specificity:	This antibody detects endogenous phospho levels of eNOS (Phospho-Ser1179) at Human:S1179, Mouse:S1178, Rat:S1178
Immunogen:	Synthesized peptide derived from the human eNOS (Phospho-Ser1179)

Post Translational Modifications	Phosphorylation by AMPK at Ser-1177 in the presence of Ca(2+)-calmodulin (CaM) activates activity. In absence of Ca(2+)-calmodulin, AMPK also phosphorylates Thr-495, resulting in inhibition of activity. Phosphorylation of Ser-114 by CDK5 reduces activity.
Function	Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
Protein Name	Nitric Oxide Synthase 3 Constitutive Nos Cnos Ec-Nos Nos Type Iii Nosiii Nitric Oxide Synthase - Endothelial Endothelial Nos Enos
Database Links	Reactome: R-HSA-1222556 Reactome: R-HSA-1474151 Reactome: R-HSA-203615 Reactome: R-HSA-203641 Reactome: R-HSA-203754 Reactome: R-HSA-392154 Reactome: R-HSA-5218920 Reactome: R-HSA-9009391
Cellular Localisation	Cell Membrane Membrane Caveola Cytoplasm Cytoskeleton Golgi Apparatus Specifically Associates With Actin Cytoskeleton In The G2 Phase Of The Cell Cycle Which Is Favored By Interaction With Nosip And Results In A Reduced Enzymatic Activity
Alternative Antibody Names	Anti-Nitric Oxide Synthase 3 antibody Anti-Constitutive Nos antibody Anti-Cnos antibody Anti-Ec-Nos antibody Anti-Nos Type Iii antibody Anti-Nosiii antibody Anti-Nitric Oxide Synthase - Endothelial antibody Anti-Endothelial Nos antibody Anti-Enos antibody Anti-NOS3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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