| Tissue Specificity | Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum. |
| Post Translational Modifications | Phosphorylated by NFATC-kinase and GSK3B.phosphorylation induces NFATC1 nuclear exit and dephosphorylation by calcineurin promotes nuclear import. Phosphorylation by PKA and DYRK2 negatively modulates nuclear accumulation, and promotes subsequent phosphorylation by GSK3B or casein kinase 1. |
| Function | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function. |
| Protein Name | Nuclear Factor Of Activated T-Cells - Cytoplasmic 1Nf-Atc1Nfatc1Nfat Transcription Complex Cytosolic ComponentNf-AtcNfatc |
| Database Links | Reactome: R-HSA-2025928Reactome: R-HSA-2871809Reactome: R-HSA-4086398Reactome: R-HSA-5607763 |
| Cellular Localisation | CytoplasmNucleusCytoplasmic For The Phosphorylated Form And Nuclear After Activation That Is Controlled By Calcineurin-Mediated DephosphorylationRapid Nuclear Exit Of Nfatc Is Thought To Be One Mechanism By Which Cells Distinguish Between Sustained And Transient Calcium SignalsTranslocation To The Nucleus Is Increased In The Presence Of Calcium In Pre-OsteoblastsThe Subcellular Localization Of Nfatc Plays A Key Role In The Regulation Of Gene TranscriptionNuclear Translocation Of Nfatc1 Is Enhanced In The Presence Of Tnfsf11Nuclear Translocation Is Decreased In The Presence Of Fbn1 Which Can Bind And Sequester Tnfsf11 |
| Alternative Antibody Names | Anti-Nuclear Factor Of Activated T-Cells - Cytoplasmic 1 antibodyAnti-Nf-Atc1 antibodyAnti-Nfatc1 antibodyAnti-Nfat Transcription Complex Cytosolic Component antibodyAnti-Nf-Atc antibodyAnti-Nfatc antibodyAnti-NFATC1 antibodyAnti-NFAT2 antibodyAnti-NFATC antibody |
Information sourced from Uniprot.org
