Anti-Phospho-NACA-Ser43 antibody (9-58 aa) (STJ91263)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human NACA around the phosphorylation site of Ser43 at the amino acid range 9-58
General Information
| Short Description | Rabbit polyclonal anti-Phospho-Nascent polypeptide-associated complex subunit alpha-Ser43 (9-58 aa) for use in IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NACA |
| Gene ID | 4666 |
| Uniprot ID | NACA_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human NACA around the phosphorylation site of Ser43 at the amino acid range 9-58 |
| Immunogen Region | 9-58 aa |
| Specificity | Phospho-NACA (S43) Polyclonal Antibody detects endogenous levels of NACA protein only when phosphorylated at S43. |
Additional Info
| Post Translational Modifications | Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation. Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization. |
| Function | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. |
| Protein Name | Nascent Polypeptide-Associated Complex Subunit AlphaNac-AlphaAlpha-NacAllergen Hom S 2 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusThe Heterodimer Is Located Mainly In The CytosolAnd The Homodimer In The Nucleus |
| Alternative Antibody Names | Anti-Nascent Polypeptide-Associated Complex Subunit Alpha antibodyAnti-Nac-Alpha antibodyAnti-Alpha-Nac antibodyAnti-Allergen Hom S 2 antibodyAnti-NACA antibodyAnti-HSD48 antibody |
Information sourced from Uniprot.org